Personally, I think 100% runs should be insane, so beyond what any sane or regular person could complete, it is truly an achievement to behold; obviously, everything on the list needs to be completed only once. In that list, all I can think of is:

-tap one of every single pure/normal/impure node with a mk 3 miner or extractor (one pure/normal/impure for iron, one normal/impure for uranium, etc.)

-complete every milestone + phase 5 and beat the game

-complete all the MAM research (holiday or not if this is a stupid level 100%?)

-collect every collectible alien artifact until ADA stops letting the entity talk to you (100% the voice line chain)

-collect only 1 of every type of slug because 1242 slugs would be too much to ask of a human being

-automate every automatable item (the factory must grow)

-craft every non-automatable item

-drive every vehicle

-unlock every hard drive upgrade and alternate recipe

-find every tape

-obtain 1 of every type of fauna (leaves, wood, berries, nuts, agaric, alien remains)

-in the above, kill/tame 1 of every type of mob in the game

-get 3 stars in every level of the packaging minigame in the hub

-finish every steam achievement not already acheived by this point

-and finally, buy every item in the awesome shop.

a lot of the repetitive stuff (taming doggos, killing mobs) only needs to be done once, or in the case of alien artifacts, until a set milestone. everything here is quantifiable, achievable, and most importantly, leaves nothing out. Some things also don't need to be added, in the process of automating every item, one would have to build every building.

satisfactory is a game with... A LOT to do, and it's kind of in the spirit of the game for 100% runs to be as overdone as possible in terms of what's possible in the game itself.

stuff i didn't add as i don't believe it adds anything to the run, but could be considered for the 100% godless run since it's technically possible

-destroy every gas pillar/spore flower (these don't respawn so it could be added)

-completely reveal the map (honestly could be added)

-fly with every type of fuel (automating the fuel is fine imo)

-build every single buildable and decoration (i think unlocking is enough)

-collide with the hitbox at the very top of the space elevator (this is just kinda funny)

-tap every node (too repetetive)

even with everything here i think i may be missing something rather than having too much. I do understand that a more streamlined 100% will probably be what gets adopted, but i'd love to have satisfactory be the horror of 100% speedruns