Does ending the run have to be the destroy ending or can it be any ending? Because I believe shooting the god child is the quickest way to end the run.

Update: Just realized about the Extended cut version. So nvm then lol

For NG+ it doesn't matter which ending as it depends on if you destroy the collector base in ME 2 if you get destroy or control. For NG you only get the default one option as without extended cut is faster.