C:\Program Files (x86)\Steam\steamapps\common\Cyberpunk 2077\r6\config

Open inputUserMappings.xml in notepad (save a copy of the original somewhere else if you want).

Under the “LOCOMOTION” heading, jump is the first option.

Delete this:

<button id="IK_Space" overridableUI="jump"/>

Replace with this:

<button id="IK_MouseZ" />
<button id="IK_MouseWheelUp" />
<button id="IK_MouseWheelDown" overridableUI="jump"/>

Save the file.

When you open the game, reset your keybindings to default and jump should be bound to scroll wheel.

Make sure you press "apply" after the pop-up message.

Rebind weapon up and down to something else.