I currently know of 3 big skips in the game:

Black Thunder (biggest) Weighting Room Lift (least big)

Does anyone know about any big skips in other rooms?

I just submitted my Any% run attempt a little bit ago and was planning on doing a run without using the Black Thunder screen. Is anyone else doing this? I only see one attempt on the board... I was also thinking of doing something like an All Rooms, or High Score run, but see no category for those yet...