There are several launch arguments I've found in the exe of the PC version of the game:

-timing

-unitTest

-outputwatch

-saveoutput

-videomode

-1

-windowed

-novsync

-multiexe

-break

-texstreamnolim

-noshadows

-nofocusinput

-texstreamlowres

So far I noticed any changes only with windowed and novsync, but maybe other arguments do something as well. It's unclear if they useful for speedruns or can give some advantage, but we might want to consider them in the future. Maybe some of the arguments need also some value to work.

To use the arguments (for example, -windowed) open the settings of the game shortcut and add the argument after the path of the game like this: "D:\Games\The_Incredible_Hulk_Win_Files_EN\Game Files\Hulk.exe" -windowed

This will launch the game in window instead of a fullscreen. You can also use several arguments at once, just add each of them one by one.

Update: "-novsync" actually really helps to increase speed of the game! At least map opens and closes faster, plus loading time decreased for some points. I tested it on canister dupe glitch and with novsync option it's just awesome! However, it also makes Hulk look down when he jumps. I don't know why, but it just does it. I don't think it's a bad thing, but you need to get used to it.