hey recently ive been routing out a 100% route and realized that there is no way to use cheats to benefit the run. Then again I'm no expert so I figured I'd ask is there an advantage to using any cheats in a 100% run?

As far as I know, no, there are no advantages to using cheats. You could use it to make the run safer by doing the hardest levels first, but otherwise its kinda useless.

I don't believe so, but there's no way that I'm aware of to exclude variables from specific categories.