Honestly, the best thing I can say is try one and post the video here. Then, we can leave it up to everyone. Personally, I don't think this would be a thing, but this would be a community decision not my own. ;)
so i tried doing a blindfolded speed run. there's no option to turn off the music, which is pretty loud. i can hear things like items and the whistle and the announcer, but things like movement and which arm is punching is super hard. i also found that skillshot against even a level 1 cpu to be difficult. as for the matches, i won by spamming retorcher. if someone wants to work on this category, good luck
Probably a dead thread, but I've been messing around in the category and have been slowly learning the random, very subtle audio queues for things. Ironically though, the most helpful queues are in the vibrations on the joycons. Still trying to figure out skillshot blindfolded, but I can at least tell if I'm the one hitting the targets.