Well, There is currently two guides regarding Wesker and Jill's fight
http://www.speedrun.com/re5/guide/3gvuc http://www.speedrun.com/re5/guide/304li
It's possible on different difficulties It's a bit inconsistent, but it's certainly possible.
I also have questions regarding if some glitches are legal? As well as the oil field skip?
Oh, apology I missed the small remark about it being done with Sheva, I'm happy to say we have a new runner that is currently trying to run only as Sheva, http://www.speedrun.com/run/zxv2p88y
I'm sure he'd be happy to research with you any strategies of using her for the speedrun. Do consider watching his run,
If you're talking about the Jill part of it then yes, either character can do that, the set up will just be different. In my co-op runs Auddy (Sheva) is the one shooting Jill.
I think we're talking solo here so as far as the Wesker part I wouldn't know about that.
Yeah I watched your run before not recent though but it was interesting... I speedrun this game more than re4, becuase i have it for X360, and re4 for wii so i dont play re4 much