STE (Something Truly Evil) serves as a condition in the game when you acquire 4 STE events within one run. When encountering STE, you can either die by reason damage or stamina damage, or defeat them.

I feel the merit of an STE speedrun, specifically defeating STE would have it's own nuance and strategies to be deemed worthy for its own category. I feel the standard rules for this category should be Cultist, any character, all card packs enabled, any timeline is available, any OLD GOD, any background and it does not matter what perks are enabled.