Strategy developed by Solstitium from the ICS.

Doing Adventure on insane needs speed and efficiency in the early game, then careful planning in the later game. For the most part, completing the level only requires a good amount of in-game knowledge. However, there are some important points I shall detail below.

1. When fighting the whip spiderling next to the nest entrance, try and surround it to limit losses to the AOE.
2. Starving out the opposing leafcutters is a must. Do so by interrupting their harvesting lines. Maintain a large reserve (200+) while doing so, but try to have at least a few taunt majors fighting. Do not select stun.
3. Once you’ve eliminated the leafcutters, leave your majors inside the nest while the media and workers gather from the leafcutter nest. Use the food to build more majors. You’ll want 19 if possible.
4. While you are harvesting, there’s a good chance the trap-jaws will attack you. Eliminate them once they do. Their nest will provide a massive amount of food.
5. Once you have 19 lvl 1 majors, expand the media chambers so you have 50 of them. This allows their flashheal to have a greater effect. After this, start upgrading the majors. Note you’ll want some more nest workers too.
6. When fighting enemies such as the Uber leaf-mimic, send the workers to fight as well. This Uber has a damage cap of six, meaning the quantity of units dealing damage is more important than the quality of those units.
7. When fighting enemies such as the Uber Velvet Worm and Uber Whip Spider, only send in your majors to fight (you should have 24 lvl 3s at least). This is because of their enormous resistance to damage (80% from being under 40% HP and the additional 20% from reaching a certain colony level), shockproof as it will prevent them from being instantaneously killed, and finally sharp. Because of the enormous damage dealt by the AOE and base attacks of both these creatures, they will do more damage to themselves through the 65% reflected by the majors than the majors themselves. Between them, these two Ubers should only cost you 600 food to kill.