I slowly re-routed parts of the game over the last 2 years , and now I know more about how the game works, mainly how exp works so moved around where I grind exp or used a worse weapon in order to get more hits per enemy because exp is awarded on hit and doesn't matter on damage so more hits per hours = more exp per hour.
My Guy split was 30:2x, 5 minutes faster than my previous PB because of new grind area and could of been sub-30. I had bad luck on the first grind of sacred nut so lost quite a bit of time there. I also had really bad luck on Senpi 1 with 3 misses causing me to fail the fight (~2mins) and do it again. I opted to move the long grind to before Senpi 3 in ordered to optimize exp with the weaker knife instead of getting the stronger Eros sword. The rest of the run was somewhat average outside getting lucky with a 3/3 on potion drops. I was low on money at the end I think also because the Knife for long grind so I couldn't revive MC so I risked it on Terarin and hoped that because Guy was one level higher than normal was enough and then got really lucky with 11 crushing attacks and 4 dodges with only 2 misses to just barely get a PB with 2 sacred nuts to spare
Sub 4:20 is great but I was +15 minutes on Senpi 1 when I should of saved time on that split and also lost ~5 minutes on having to get more stones during the key bosses and another ~2 minutes lost on having redo Senpi 1 fight so quest for sub 4 hours might begin soon after some more optimizing of the route.