Saw this video on Youtube. It is helpful for speedrunning because it allows you to skip finding the wedding ring and giving it to Angie, getting the envelop and giving it to Jerome, and hearing about Vigo from Monica. It seems you do need to make a SNS post in Chapter 2 to avoid getting Seduced by the Snake in case you don't find the wedding ring in Chapter 1 though. ()

Since Purgatory is triggered in a similar way, I wonder if this ending can be skipped as well. In this case it won't be necessary to find Monica.

Edit: It works! So "You can't use that here" would overwrite the trigger of Purgatory and Pre-established Harmony.

I may have laughed my ass off with the skip, that will be incredibly handy in a run

Such a surprise. Good news: you don't have to post on SNS in Ch.2 since the game seems too confused to give you "Seduced by the Snake" when you skip "Purgatory" in this way Bad new: So... Monica can't be completely skipped in Ch.3. I wonder if it's still possible to skip the antibiotic though.

yea I tinkered with if monica could be skipped and no....you just die at the ending. You maybe/should/possibly be able to skip getting the antibiotic since when you talk to Eric twice, you call Kelly....from there you can/should just click on the vent and continue...

I say could, should, and possible since I haven't tested it out on my end : (

I just tested it out. Finding Monica and talking to her twice are enough to make her show up at the final scene! The antibiotics can be skipped. Now it kinda makes sense that there is a branching point for "did you find Monica." It seemed a little redundant at first since simply finding her doesn't get you anywhere. All these signs together strongly imply that the player is supposed to be able to get to the final scene without finding Monica at one point during development. I didn't check if opening the container was enough or you had to talk to Monica though.

I would imagine that you would have to talk to her to trigger the game to branch you into said different path, I will have time tomorrow morning to test it out.

if I were to guess, you would have to talk to her once/twice and then leave, go to eric, talk to him twice, call kelly then the vent...

EDIT: ALSO! I had a thought and will test it out tomorrow, but do we have to find Jessica now? Since the game is so confused do we have to really open that locker in chapter one?

You absolutely do. Not finding Jessica leads you to "It's all too late" ending at the end of Chapter 2, which is before any of the glitches take place.