So in the new game update, you cannot jump on the house to get the second chest of the game. i haven't tested the other chest yet but there a chance its the same thing for some of them

The skill are also different, which mean you cant get 2% more stamina.

Are the previous run invalid or are we gonna add a new category for the full game

I think a full game category will be added, because run times vary due to which version of the game you play. Like one version has less recipe cost overall. So yes I do believe a new category should be made :D

even more change, you cant buy a pickaxe in the sotre, you cant sell your green powder to the store they used to, you need to sell it to martha the relic are random (i dont know if they were random before but youre not garanteed the 2 old part)