Once your game is properly installed, you can either mount your ISO using something like DAEMON Tools, or if you want to play it without the need for a CD-ROM, do this:

The config file is in the Registry Editor located at either: "HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Disney Interactive\Emperor's New Groove\1.0" or "HKEY_CURRENT_USER\Software\Classes\VirtualStore\MACHINE\SOFTWARE\Wow6432Node\Disney Interactive\Emperor's New Groove\1.0"

This video guide also demonstrates this process (ignore the GD music lol)