It's possible to skip the health pickup after the first slow-mo room, but chance of death is extremely high. The enemies on the street as well as the green shirts with revolvers have armor piercing rounds and bot fast reaction speed. So all it takes is 1-2 shots and you're dead.

Smoke is used on the street, double green shirt room, and two guys on the far right because it doesn't lose time, but it reduces the odds of taking health damage.

Shooting the small bomb by the big bomb destroys a security camera which would cause extra enemies to spawn while trying to defuse.