This skip was found by me. Although the dungeon can be completed without defeating any boss other than the last; it is very slightly faster to skip to the final boss instead of running there. (We're saving the frames!)

Items used:

• Wearing: Lv70 full Mastery crafted Dragonflight gear, 3x Azerite Armor with the Longstrider trait, speed enchants
• Before entering: Fried Bonefish, Charged Phial of Alacrity
• During run: Nitro Boosts, Vrykul Drinking Horn