Crossbow seems pretty good right now because of it's high damage spread. Dual shotguns are also very good because of how much damage they do
I'd put my money on Crossbow. It has inherent piercing (which is usually a perk) and good damage on the entire spread (higher if you hit more than one bolt, which is easy), which makes it great at crowd control when the later levels are just enemy spam. Even if you miss your intended target, one of your bolts have a decent chance of hitting something else (and perhaps the thing behind it), so damage rarely goes to waste.
Add on top of that it's seemingly immune to perks that add extra recoil or spread for some reason, and from personal experience it seems to roll much higher on chance-based things like elemental effects (and the god tier perk Homing Shot), makes it the easy go-to for any serious runs.
In the last day or two new categories have been introduced including flawless%, Island 90%, and multiplayer hardcore runs. If anyone has suggestions for new categories feel free to comment on this post, create a new thread, or post it in the speedrunning discord server.