When starting to run this game there are a few things to take note of in the PC version:

Shift Key is a great shortcut to start Fast Forward Esc is used to reset a Frame if you get caught Spacebar will pause the Frame

Ideally you'll never have to used Space Bar or Esc key in a run, but it can save some sticky situations.

If (and I hope you would) use mouse for the run please note that the keyboard and mouse can not simultaneously input, that being said it's safest to make sure the Shift input is done first so the Frame progresses at the fastest possible time.

It's also noteworthy that as you pick up a panel the game pauses, thus; the less time you take to click and drag the better, also, the least amount of clicks to solve the puzzle is best (there's also multiple animations through a panel and some are faster than others!)