Feel free to post any small time saving efforts here!

¤ Motion sensors are not needed for any objective in the game and can safely be skipped. You just need to restart the computer.

¤ You don't actually need to deploy the nerve gas, you just need to reach the hallway where you can see the eggs across the room. Once you cross the line into that last hall (there will be a medpack on your left), you can safely die and you'll be able to activate mainland comms. You can check out that part of my speedrun if you want to see it in action. There's no visual confirmation that it happens, I just observed a variable changing in memory to learn about it.

¤ After activating any program on the computer, you can click on its icon to return to the main menu. However, if you do this with Gate Operation, it'll take you back to the Gate Selection screen before the main menu, so I suggest you save it for your last computer action then exit. For example, if you need Security Level 2 then Gate 2 (for Raptor Nest), do Sec Level 2 first, then Gate 2.

¤ You can turn faster in buildings by holding the shoulder button while you turn. So if you hold Left and L, you'll turn left even faster. I use this when I need to turn large angles, such as 180 to leave a room or a non-precise 90 degree turn. Due to the low framerate and increased turning speed, it can kind of throw you a bit, so don't use when you need more tight of a turn. Practice it and you'll figure out when is best to use it.

¤ When you get into an elevator, use Left + L or Right + R to spin faster to face the door. When the door closes on you, it will shift you to the center of the elevator and rotate you to face the door. This action is slow and wastes time, so the closer you can be to facing the elevator door, the better.

After clearing the ship of dinos, you can jump across the river instead of going around the forest to take the bridge to Raptor's Den. If done correctly, it saves around 3 or 4 seconds, but the timing is quite difficult to get.

See this gif for reference :

The trick is to jump on the edge of the water (you'll know you're at the right spot if you can't move left or right). It's also possible to do it on the way back too, it saves around the same amount of time but it's a bit more difficult. My trick on the way back is to jump on the edge too, but then press down and you'll see Grant putting his foot forwards. If the tip of his shoe is over the water you should be fine for the jump. There's also an example of that in the gif I linked, the first time I try to jump back, I'm placed incorrectly.

The timeloss on this is very costly since you'll die and respawn at the last building you entered, I don't suggest using this technique unless you're consistent at it.

I saw this trick on Leon's route after clearing the ship for the second time. I couldn't bring myself to risk warping back to the ship on a mistake just to save 5 seconds ;_;