All run encounters on the map are different (except the Silversmith's House), but what would a perfect run look like? Here:

1:

From Dirtwater to Cavern Canyon: Silversmith's House

From Dirtwater to Silversmith's House: Impact Meteor (750 Meat)

From the Silversmith's House to Railroad Camp (East): Impact Meteor (750 Meat)

From Railroad Camp to Gustavon Gulch: Impact Meteor (750 Meat)

Now With 1337 Starting Meat, the 3 Impact meteors, and the 2 Treasure Boxes at Gustavon Gulch for 1000 Meat Each, You have 5587 Meat, Enough for The Turnip Crown

From Gustavon Gulch to Railroad Camp to Silver Plater: Fort Alldead.

From Silver Plater to Fort Alldead: Dynamites

From Fort Alldead to Railroad Camp (West): Modern Snake Oiler (Forced)

From Railroad Camp to Breadwood: Military Cemetery (Immediatley Go There)

From Military Cemetery to Roy Bean's House: Impact Meteor (750 Meat) (Forced)

From Roy Bean's House to Buffalo Pile: A Cow Cult Brigand (IDK Why)

From Buffalo Pile to Railroad Camp (West): Reboot Hill

Wandering from Railroad Camp: Nex-Mex Book (Forced)

Old Railroad Camp to Frisco: Last Custard Stand

Here to Post a New perfect run.

Take any horse Except the Pale Horse

Dirtwater to Cavern Canyon: Silversmith's House

Cavern Canyon(Immediately travel after the decent Wine) to Silversmith's House: Daveyard

Silversmith's House to Railroad Camp: Unlock Old Mission

Railroad Camp to Gustavon Gulch: 4 Dynamite

Gustavon Gulch to Railroad Camp: Nothing

Railroad Camp to Silver Plater: Humming Cave

Silver Plater to Humming Cave: Snake Oiler Book(Forced)

Humming Cave to 2nd Railroad Camp: Perfessor's House(Go There Immediately)

Perfessor's House to 2nd Railroad Camp: Meateor(Forced)

2nd Railroad Camp to Breadwood: Curious Copse

Breadwood to Curious Copse: El Vibrato Monster(Get a Battery)

Here You must get the El Vibrato Model Bridge

Curious Copse to Railroad Camp: Nothing

Railroad Camp to Frisco: Nothing

And you should easily get Sub 3:45