This post will receive updates over time if/when anything new is discovered. There are some cosmetic changes as well but for the sake of this post, only changes relevant to speedrunning will be discussed.

This is all based on the PS4 release of the game, but it's safe to assume that these apply to all releases of Pac-Man Museum+.

• Loading times are increased compared to Wii/Wii U. It takes about 3 seconds for levels to load both when selecting them and after dying. It's hard to measure exactly since not every level takes the same amount of time to load on Wii/Wii U, but a good estimate is somewhere in the ballpark of 10-15 seconds over the course of an entire run.
• The first section of 4-5 and the second phase of 5-Boss have lag issues, both areas running at about 75% speed almost the entire time.
• Most moving platforms move in slightly different ways. The moving ghost platforms in 3-3 accelerate to higher speeds over the course of their cycles instead of maintaining a constant speed throughout, and the platforms after 4-3's first gate don't stop before turning around.
• When Pac-Man becomes airborne after a slope boost or when using a bounce pad, he takes way less time to accelerate in mid-air and can also vector to increase overall distance gained. So far, this has three significant uses:

1. 2-3 skip is now possible.
2. A new shortcut that skips most of the first section of 4-4, which has been confirmed possible on Namco Museum Megamix but is way harder, is doable.
3. 5-1 triple gate skip is now humanly viable.

• Bounce/lava boosting is still possible, but much harder because a frame perfect button press is required.

All in all, with everything taken into consideration, it's safe to assume that the port on Pac-Man Museum+ could save at least a minute over Namco Museum Megamix in Any%. The other categories likely won't have anywhere near as much timesave, and thus those likely won't be affected. It is still being discussed how to handle comparing Museum+ runs to NMM runs.