Hello, I was just wondering if there are specific gambatte settings that need to be used similar to how BGB has a speedrun setting. Thanks!

The default settings are fine. In older versions, we concluded that changing v-sync settings altered the frame rate, so I'd suggest refraining from touching graphics settings that resemble something like that. For a more complete and up-to-date answer, I'd suggest contacting the developer of the program.

Ok great, thank you!