I started fresh with a different starting seed and put a lot of time optimizing the route. I think I got lucky with the seed I chose as the early game ended up being very fast though a few of the later levels are admittedly kind of slow. I do believe discovering a God Seed would take a significant amount of work due to how random this game is, but I can see a sub-4 minute run happening in the future.

Played on BizHawk 2.6.3