(not that new since I recommended similar things a few years back, just fleshing them out more)
Damageless - Complete a run without taking any damage. "Damage" would just be whenever the yellow border surrounds the germ (so soap/mouthwash would not count as damage). This one might be possible, the only part that I'm not sure about are the bloodstream sections since the macrophages constantly attack the germ. Damageless is most likely possible in Nelson & Dump-it, but trumpet & crumpet bloodstreams would be the most difficult as the B-cell glitch would still allow for macrophages to attack you, so a different strategy is needed there.
100% - Collect all of the bonuses in the Gain Entry/Lungs sections (bonuses in bloodstream spawn constantly at random intervals, so that section would play as normal). This type of run is possible and would probably add about 2-3 minutes to the any% time, mainly due to the GE sections having a lot of bonuses to collect. The only section that wouldn't change is Dump-it lungs, since there are no bonuses to collect there as far as I'm aware.
I think these categories could be interesting since both would require new strategies/routes to be implemented. I've considered bringing back the "Glitchless" category within any%, but the already existing glitches (besides resize glitch) don't save that much time compared to a glitchless run. If there's enough demand for these (really only 1 or 2 other people) then i'll add these categories