Heya peta. I'd love to explore some of the nitty gritty parts of the game.
Cloud Master is an auto-scroller where the time saved consists of 2 factors, quick shopping and more importantly quick boss fights.
As a basic strategy - the strongest main weapons are BRB and RR (B-Blue, R-Red) since you can only have 6 total bullets on screen at a given time. BRB is better if you get up and personal with bosses and hit their weak point, but I think RR is the overall better choice, even for TAS. (Requires further testing)
The Crescent Weapon (which you get by powering RR up) however goes through enemies and therefore not getting absorbed by the boss means it's overall a weak DPS choice.
Sub-weapons will require a bit more testing as well, hope to get to doing this some point. Luckily there are duplicates, as well as some useless weapons.
Will update with what I find hopefully this week :)
One note, if you are really good with super fast movement, you can grab all the Fs (Character Speed Upgrades) and make boss fights a bit quicker although this is a lot harder to control your character.