going off of turbodog's notes, i'd say that all the in's are necessary and the only ones i'd say are for sure in from debatable are all notes/data logs and all bosses. Med packs are questionable especially IF you're not doing all stats and akumu can't be separated into an individual category. The easter eggs are simply that - easter eggs, and most other things mentioned shouldn't affect 100% runs unless you're doing All trophies run or something. Killing all enemies if very different from all bosses and I haven't actually seen many/any runs for any game do all enemies.

(this post probably contradicts my prior post slightly but I would like to continue the discussion further to get something more concrete)

Edit: So here are what I think are some pretty basic rules that can apply to a 100% run:

• all collectibles (personal documents,documents,map fragments,newspapers,missing persons posters, and audio tapes)
• all keys (since there are keys are only 2 keys in the lockers this shouldn't be considerably difficult and add some luck to runs since you could be lucky and find them both in ch.2 or you could find them in ch.14 after you've collected all the others) Basically any other idea we have come up with only should be included if it is part of what was mentioned above, so no need to do the Easter egg stuff, defeat all bosses. Stat's could still be debatable only because if you're going to obtain all keys (and as TurboDog72 mentioned, you can track stats) you could say that's a prerequisite for 100% but i'll leave that up to this for debate. I will say that collectibles should be a definite "in" though.

I think 100% implies that you do everything in the game regardless of any reward, Akumu mode offers no reward for completing it, trophy or in game reward so why should we ignore doing all notes, missing person flyers, newspapers, audio tapes, etc. I'm think 100% is a good idea, but it should be 100% of the game.