//First death// -At the very start you'll just want to die as fast as possible, on floor [-100] there's always gas vents to kill you, they are usually either in a large room or in a room with stairs (in this case the vents are up the stairs). THIS ONLY WORKS ON THE FIRST DEATH: After spawning hit the Sentry Angel until he kills you(100 hits), this will allow you to avoid Archangel's cutscene AND will give you a special cutscene that is shorter than the one you'd usually get, this method saves around a minute, and it's a funny easter egg :D.
*On floor [-100] there's always a room that triggers a short cutscene. You can avoid it every time you go through this floor as it will never be the only room that will lead you to the exit, so avoid it when you can. In this same floor there's also a room with the same design as this one, but you can differentiate it if there are enemies or items on the floor there. The cutscene room does not have any spawns.
//The -1600 run// -After dying go straight to the tower, you'll want to skip every enemy and collect all hearts and meat you can find, also keep in mind that you can get some good items and store them for the final run. Be sure to eat up Guryu when your HP is full in order to increase your max HP. Keep Churyu and Kenryu in case you HP gets low.
-Room exits can be either on the floor level or up a ladder. When using the minimap, the exits that appear closer to the corners of the square are more likely to be up a staircase, while the ones that are more centralized are more likely to be on the floor level. Floor exits work in a similar fashion, if they are centralized on the minimap square, it is very likely that they are on the floor level, while if they are closer to the sides, it is more likely they are up a staircase.
*Items worth storing when going through this tower: Nutritives can be pretty useful, good swords(specially something with ice damage, an ice damage parasite can work nicely as well) or cloaks can be good to get. Invincible bones are extremely useful when you're in a pinch, but you can manage without one. A Growth sword/coat can be useful as well, it does lower the xp you gain but every floor you go down with it equipped it gets +1 ATK/DEF. Firebreathing Brand (Breath fire when you level up) and Resurrect Brand can be extremely useful.
-When you get to [-800] avoid going up at the spawn, it usually leads to a Koriel room, same thing applies for floor [-1100]
-The only time you'll be able to store any item other than the Cultivating Fluid on this run is on the orb located at [-900].
-Your first and only stop on this tower run will be on [-1200], on your way there you'll find some annoying enemies such as the Sin-Monis.
It's body occupies a lot of space, and if you try running past him on corridors you'll end up pushing him with you and he'll keep sucking your HP and VT, I've found two ways of dealing with these enemies: one is stun-locking it with heavy attacks while walking through the corridor (this does take up some time, so use it as a last resort, it might be better to just push it all the way to the end of the corridor), the other method is if you find an opening in the corridor(the entrance to another room or just another corridor) you can enter this opening and then circumvent the enemy through this opening.
-Another enemy that can be very annoying is the Or-huganous.
It has a burst attack where it fires several thunder balls at you (and it hurts, a LOT), there's not much you can do except not running in a straight line when you're avoiding them or stunning them as they're about to fire.
-Once you reach [-1200] you'll have to look for Doctor Angelicus' lab, the room has a very unique design so you'll know when you reach it. To find it easily look for a Consciousness Orb, it usually is on the left on up on the floor, once you find it go to the corridor and turn when you can, that will lead you to the lab if you do it right. First thing to do when you get there is look for a fluid on the right of the entrance, if it isn't there then you'll have to reset (don't worry, it's there most of the time.), after getting the fluid kill yourself as fast as possible, remember to store the Cultivating fluid on a Consciousness orb by throwing the fluid on one, you'll need it.
//Getting Pure Water//
-After going through the first tower you'll want to punch the collector (to the left, the kid with the big head) 2 times in order to get the Cultivating Fluid, throw it at Longneck (to the right, the green guy with the long...neck...), you don't have to listen to his dialogue, after throwing it to him immediately go to the tower and kill yourself the same way you did on the start of the run.
-When you come back Longneck will have buried himself, then you'll be able to hit him 2 times and he'll drop his crystal, pick it up and throw it to the Sentry Angel. (From where Longneck was looking, go to the right and the Angel will be there guarding the Research Lab). After throwing it kill yourself again.
-After killing yourself go back to where the Sentry Angel was and enter the Research Lab, after a cutscene you'll get your Pure Water.
//The final run// -After getting the water you'll be teleported a bit ahead of your normal respawn point, go back a bit and retrieve your items from the Collector and get the Angelic Rifle from the Archangel, if needed step on the recovery disk to the left and then enter the tower for the last time, your first stop will be at [-1200], do not use the Rifle until then.
-Use Recovery A/D as often as possible since they increase your base stats if you don't have any debuffs on you.
-You can kill some enemies if you want, but if you want to be fast you better run like the wind and pray that you can get lvls later from using Torturers/Disks on later floors.
*Moon, which can drop Arrows, Ports and Experience bones.
-Avoid Gliro at all costs since if they steal your Rifle or your Water you're pretty much screwed.
Also if you see a Soconpo jumping you can angle yourself in a way that you can get a boost from the knockback, this can be really useful if done right. If you stand next to a Soconpo it might shoot an acid that corrodes your weapon and lowers it's damage, it can stack up really fast so be careful around that.
-After getting to [-1200] look for Angelicus' lab once again, after you find it you'll trigger a cutscene, after the cutscene you'll need to go through 3 dialogues, after that throw the Rifle at her and you'll receive a Recovery DX, use it at once to get the bonus DEF/ATK.
-Once you get to [-1500] look for Eliza, you'll need to give her your water to trigger a cutscene. Eliza is always found on a room with a corridor that goes UP(North).
-Now things are going to get really annoying really fast, since Suns are going to start appearing ([-1700] to [-1900] and then [-2100]), if you have an ice weapon from before it'll help you greatly, if you also have invincibility bones to spare then that's perfect, when you find a Sun on the way try to look for an alternative path, if there isn't one you'll either have to brute force your way through or warp to another room. If you have an ice weapon defeating Suns shouldn't be too hard, they can deal a lot of damage if you aren't careful. Suns can shoot a liquid that gives you Lethargy, one of the most annoying status effects that you can get, when the green wall falls apart try to stay a few feet away so you don't get Lethargy, after a few seconds it'll disappear. Suns stop appearing after floor [-2100] thankfully.
-Also with the Suns Nicl & Nicr are going to start appearing, these are minor threats but they can paralyze you with the pink gas that they can use, this can be very dangerous in a situation where you're cornered.
-When you get to [-2000] most of your troubles will be gone, now you'll have to look for the room with the Littles, it can be easily spotted because of the yellow floor that is near the gate you need to open. To find this room use the same trick as the one used for finding Dr. Angelicus' lab. After triggering the cutscene be sure you have the Littles on your inventory, if you don't then make up some space, also throw out any trash you won't use now, this last part will be very fast paced and very dangerous to run through.
-When you get to [-2800] you'll have to find Alice and give her the Littles you picked up earlier, now there are going to be a few new enemies you haven't found before on the tower such as:
Aries, who has the lowest aggro on the game but if you aggro him just run away as fast as possible, you don't want this beast near you, and
Johanna, as long as you don't hit Johanna it won't aggro on you.
-The very last enemies you'll have to be careful against are the
Hana-nip , that can confuse you and chase after you in its "car"? form and
Joe can't do much except shoot at you and sometimes charge at you, Hana is a much bigger threat, never walk on a straight line and don't stay on the same straight corridor for too long or you can get caught by the Hana.
-From here on it's just a race to get to floor [-3900] as fast as possible, when you get there then you can relax, there are no more enemies anywhere, just search for the Archangel and fuse with the Absolute God.
-Once you get to the very last floor go down and left until you find Cherub, after you do the Archangel is just one room away!
//END//
If you have any questions or suggestions or even just want to talk about the run hit me up on Discord!