You can begin your next "launch" as soon as you see the pill in Mario's hand again.

The pill will land in the flask depending on the line on the middle of the pill. The farther right that this line is within the colored region, the less time it takes.

This game loves to drop clicks. Between each throw, move your cursor just a little bit to keep it from locking up.

Keep track of what you have thrown. Each flask takes 4 pills. If you have thrown 4 blues, 3 yellows, and 0 reds, be PREPARED to throw reds, but keep your eyes peeled for the yellow.

The timer starts when you click "Play Game". You must be quick from that button to the first launch.

It seems like getting anything under 20 seconds is extremely unlikely, if even possible at all.

The best way to get a good time requires extreme reaction speeds and a bit of luck to predict which pill is going to come up as well as when you will be able to launch that pill.

One way to do this would be to keep retrying over and over again until you get 4 of the same colored pill for all three types of pills in a row, (example, 4 reds in a row followed by 4 yellows in a row, which then opens up for the 4 blues in a row), as it completely removes the need to process which color it is before launching.

I personally have had runs where this had happened but I never trusted the RNG to actually give me four in a row. My 21 second run was a 1 miss run.