Game in series: Uncharted 4: A Thief's End Category Name: Melee Only Rules and category description: Normal Glitchless Rules. You can't use any of your weapons or grenades during the run unless it's needed to progress. The only places where that's the case are: In the prologue, you need to kill 3 enemies from the first boat and 2 from the last boat. The other place is in the end of chapter 20, you need to use RPG to take down the jeep. Besides that, everything is doable with fists, takedowns or having your company to shoot for you. The difficulty is irrelevant. Here is an example of what a melee only speedrun looks like -