Can DuckStation be used to run this game? I used to use ePSXe for emus but honestly I have an easier time using DuckStation and thinking about doing some runs for the game. Just want confirmation and if so, what configurations would be needed.

Honestly, the question has never come up so i'm not 100% sure how to tackle it, fortunately the Spyro community has something for Duckstation so we'll piggy back off their rules as a quick and simple solution unless something else comes up https://docs.google.com/document/d/1Y0mHXDG0GUpJatcvBNCTePHrCWPaTVX-myNeEtvCQHs/edit

Okay. I looked over the document and basically got the idea to not impose any extreme settings that would create an unfair advantage. However, would I need to capture the game in windowed mode then? It's not super appealing to be streaming in this fashion. Maybe just verifying settings before or after run would suffice but looking for an answer on this.

Fullscreen is fine, aslong as somewhere on your stream layout you are capturing that enhancement text on the bottom right side of your game feed, which can be done by game capturing the Duckstation window a 2nd time and cropping it down to that overlay part, a quick example i made up