Requirements - Double Damage Potion At least 2 health left to perform this damage boost strat.

Time Save - So I discovered that it is possible to 1 cycle Wren. This saves at least the entire time it takes Wren to tornado around the arena, and the time it takes her to charge up her attack. (Haven't timed but its at least 10 seconds)

How to do: After avoiding all damage for the first round of her tornado, begin charging a charged strike so that it can be ready to strike. You are looking to release the strike within range of Wren at the exact moment that she releases her shots. She is vulnerable the moment the shots begin to fly. Hitting her with a charged, double damage potion hit, will set up the one cycle with regular hits if you time the first follow up hit on the first few frames that her hit stun invulnerability has dropped.

it may be possible to do 2 charges in this time, but for sure, 1 charge and max follow up hits during this time can get a one cycle and save a fair amount of time.