So it's no secret de3 is no de2 and not every de3 achievement makes a great standalone run. Spaced is sub second long, Escape Pod is already any%, Lost in Space is Decontamination 2 etc

The Truth doesn't require you to mix anything or washing the meth room. Lacking 1 digit for password is mostly fine and you get a try for free.

So as it turns out, space suit can be used to skip repairing the fans. And if you blow up the lab there's a yes/no popup screen to use escape pod even if you haven't unlocked its door. Also after you reenter the game you get moved to what is mostly the previous room. Blowing up the lab+escaping at the bedroom places you 2 screens behind so it's optimal for 100%.

Lost in Space is core of 100% with no extra endings