I was aiming for sub 4h so this was pretty nice ! I rerouted everything from scratch, and found some strats (notably Merle's Hostage Farm, manipulating Jess to enter your helicopter, destroying the Jail's gates yourself, strategic use of homeopathics...) A few mistakes/bugs so it can be improved even with the same route If you have any questions don't hesitate !

Mod Edit - nice new strats, too bad the community didn't know about them earlier.