The general route is exactly the same, yes. Boss strats are slightly different due to the knife being less OP (but still very good) at 60fps.
@LadOkapi G1 the same, knife him. Pick up the knife in library so you have 2 if he grabs you. G2 with flamethrower instead of knife. Flame him until you have 130 fuel left to one cycle him. G3 is all flamethrower 130 + 200 from cafeteria and other 200 from the boss room and 2 grenades. Instead of shotgun to the face on the floor zeds in MURF room in NEST. Use a grenade to kill them all. So you need all 4 grenades (Club room, Gun store, Sewers, the last one i dont remember right now were you pick it up) This is Leon A. Clarie i havent routed yet
I think it really depends on what category you're running. I agree that the main difference is the Knife damage, but since the Knife damage on 60 FPS PC/Console may not be optimal for killing certain bosses this leads to differences in the routes as to what guns you'll take with you. For instance, I don't know if PC 60FPS Leon A Standard has something special about it, but the route of PC 120 FPS Leon A Standard is not exactly the same as Console Leon A Standard. On most of the runs placed in the top spots on Console the runners don't go for the Shotgun, but take the Flamethrower, which is skipped in PC 120 FPS.
Anyway, I think that your best option is to study what category you're going to run both on 120 FPS and 60 FPS / Console to establish your optimal strategy. I don't think there is an answer to your question (at least if framed that way) that will be very helpful. =)